Endocrine Abstracts

Introduction: LDL cholesterol (LDL-C) is usualy estimated using the Friedewald equation. This equation assumes a fixed factor of 5 for the ratio of triglycerides to very LPL cholesterol (TG:VLDL-C); however, the actual TG:VLDL-C ratio varies significantly across the range of triglyceride and cholesterol levels. A new method was proposed by Martin, S and co-workers using NHANES data. We aimed to evaluate the concordance Friedewald formula with the new method for LDL-C estimatio...

Introduction: Sulphonylureas (SU) are an effective therapy for type 2 diabetes (T2DM). As insulin secretagogues, hypoglycemia is a potencial adverse effect. Hypoglycemia may cause neuroglycopenic brain injury, which can mimetize stroke and infections of the central nervous system. Case ReportThe authors report the case of an autonomous 71 year-old woman, with medical history of hypertension and T2DM, treated with enalapril and gliclazide, that was admitted in the Emergency Roo...

A 30-year-old male was admitted to the neurotraumatology ward after head trauma with cerebral concussion, subdural & subarachnoidal haemorrhage. The Endocrinologist was called to evaluate high urinary debits. The patient was healthy until 4 years before admission. He enrolled on variate patterns of alimentary restriction that resulted in the loss of 28 kg. Since then he had visited multiple doctors (Cardiology, Haemathology, Psychiatry, Gastroenterology, Urology, Endocrino...

Introduction: Erectile dysfunction (ED) is highly prevalent and negatively impacts the patient’s and the partner’s quality of life. It is a well-established red flag for ongoing neuro-vascular disease and a predictor of coronary, cerebral and peripheral arterial disease (PAD). Our aim was to document how often do clinicians investigate ED and use it as a predictor of neuro-vascular pathology to trigger a thorough revision of cardiovascular risk factors (CVRF). This a...

Introduction: Maturity-Onset Diabetes of the Young (MODY) is a rare cause of Diabetes Mellitus (<5%), resulting from autosomal dominant monogenic defects.NEUROD1 gene is expressed in pancreatic and neuronal cells, being associated with MODY type 6. Mutations in NEUROD1 gene are reported in 20 families worldwide to date. Heterozygous variant c.616C>A, p.(His206Asn) has never been described.Case Report: The authors report a c...

Introduction: Pseudohypoparathyroidism (PHP) is a rare disorder characterized by parathormone (PTH) resistance, caused primarily by genetic defects involving the alpha-subunit of the stimulatory G protein. Biochemical and molecular analysis classify pseudohypoparathyroidism into types I-a, I-b, I-c and 2. We report a case of PHP I-b in an adolescent presenting with a neurological disorder.Case Report: 11 years old female patient, with no relevant persona...

Introduction: Hyperandrogenism is a relatively common medical condition, however severe post-menopausal hyperandrogenism should raise suspicion of a malignant etiology and prompt clinical evaluation. Furthermore, androgen excess has also been associated with severely decreased quality of life. As such, identification of its cause and adequate treatment should not be delayed.Case Report: We report a case of a 66-year-old woman, who had a 5-year history of...

Introduction: Graves disease (GD) is a frequent cause of primary hyperthyroidism and often presents with weight loss. Weight gain beyond the premorbid state is often reported and could be a challenge during patient’s management. Treatment modalities, disease remission and biochemical parameters at the diagnosis have been described as predictors of weight changes in patients with GD. Objectives: To evaluate the determinants of weight changes in GD tr...

Background: Management of obesity and overweight greatly improves glycemic control in type 2 diabetic (T2DM) patients and also provides positive impact in other cardiovascular risk factors in this population.Objectives: Evaluate the impact of weight and weight variability in subclinical inflammation and comorbidities of T2DM patients, over the last decade.Methods: Retrospective study of 1900 patients with T2DM, with a minimum of 2 ...

Introduction: Mauriac syndrome is characterized by delayed growth and development, obesity, hepatomegaly and elevated transaminases in type 1 diabetes mellitus (T1DM) patients who have poor glycaemic control. Usually recognized in adolescence, when growth failure and pubertal delay became notorious.Case report: A 19-year-old male was referred to the Endocrinology Department due to short stature. He was severely distressed about his stature and younger ap...